消化管疾患の病理学研究

主な担当メンバー：牛久綾、国田朱子、阿部浩幸、六反啓文、西東瑠璃、日向宗利、山澤翔、深澤京

消化管疾患の病理学研究が当教室の研究の柱で、特に胃癌の病理学研究分野をリードしてきました。今年行われた9年ぶりのWHO分類改定では当教室から発表された多くの論文 (下記参照) が新たに引用され、またこれらの成果が評価されて深山前教授が主編集者の一人として選ばれ改訂作業に大きく貢献されました。
ここでは最近のいくつかのプロジェクトを紹介します。

胎児型形質胃癌
EBウイルス関連胃癌

新WHO分類で引用された文献

（教室所属者が筆頭著者または責任著者論文に限る）

  1. Ushiku T, Uozaki H, Shinozaki A, et al. Glypican 3-expressing gastric carcinoma: distinct subgroup unifying hepatoid, clearcell, and alpha-fetoprotein-producing gastric carcinomas. Cancer Sci. 2009 Apr;100(4):626-32.
  2. Ushiku T, Shinozaki A, Shibahara J, et al. SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric carcinoma from hepatocellular carcinoma. Am J Surg Pathol. 2010 Apr;34(4):533-40.
  3. Ushiku T, Matsusaka K, Iwasaki Y, et al. Gastric carcinoma with invasive micropapillary pattern and its association with lymph node metastasis. Histopathology. 2011 Dec;59(6):1081-9.
  4. Ushiku T, Shinozaki-Ushiku A, Maeda D, et al. Distinct expression pattern of claudin-6, a primitive phenotypic tight junction molecule, in germ cell tumours and visceral carcinomas. Histopathology. 2012 Dec;61(6):1043-56.
  5. Abe H, Hino R, Fukayama M. Platelet-derived growth factor-A and vascular endothelial growth factor-C contribute to the development of pulmonary tumor thrombotic microangiopathy in gastric cancer. Virchows Arch. 2013 May;462(5):523-31.
  6. Ushiku T, Arnason T, Ban S, et al. Very well-differentiated gastric carcinoma of intestinal type: analysis of diagnostic criteria. Mod Pathol. 2013 Dec;26(12):1620-31.
  7. Ushiku T, Arnason T, Fukayama M, et al. Extra-ampullary duodenal adenocarcinoma. Am J Surg Pathol. 2014 Nov;38(11):1484-93.
  8. Shinozaki-Ushiku A, Kunita A, Fukayama M. Update on Epstein-Barr virus and gastric cancer (review). Int J Oncol. 2015 Apr;46(4):1421-34.
  9. Ichimura T, Abe H, Morikawa T, et al. Low density of CD204-positive M2-type tumorassociated macrophages in Epstein-Barr virusassociated gastric cancer: a clinicopathologic study with digital image analysis. Hum Pathol. 2016 Oct;56:74-80.
  10. Urabe M, Ushiku T, Seto Y, et al. Pathologic Response of HER2-positive Gastric Cancer to Trastuzumab-based Chemotherapy. Am J Surg Pathol. 2016 Oct;40(10):1326-33.
  11. Ushiku T, Ishikawa S, Kakiuchi M, et al. RHOA mutation in diffuse-type gastric cancer: a comparative clinicopathology analysis of 87 cases. Gastric Cancer. 2016 Apr;19(2):403-411.
  12. Saito R, Abe H, Kunita A, et al. Overexpression and gene amplification of PD-L1 in cancer cells and PD-L1+ immune cells in Epstein-Barr virus-associated gastric cancer: the prognostic implications. Mod Pathol. 2017 Mar;30(3):427-439.
  13. Yamazawa S, Ushiku T, Shinozaki-Ushiku A, et al. Gastric Cancer With Primitive Enterocyte Phenotype: An Aggressive Subgroup of Intestinal-type Adenocarcinoma. Am J Surg Pathol. 2017 Jul;41(7):989-997.
  14. Abe H, Saito R, Ichimura T, et al. CD47 expression in Epstein-Barr virus-associated gastric carcinoma: coexistence with tumor immunity lowering the ratio of CD8+/Foxp3+ T cells. Virchows Arch. 2018 Apr;472(4):643-651.