主な担当メンバー：牧瀬尚大
骨軟部腫瘍の病理診断の正確性や迅速性の向上に役立つバイオマーカーの開発や、新しい腫瘍型（ないし亜型）の発見を目指した研究を行っています。
＜参考文献＞
- Makise N, Yoshida A, Komiyama M, Nakatani F, Yonemori K, Kawai A, Fukayama M, Hiraoka N. Dedifferentiated Liposarcoma With Epithelioid/Epithelial Features. Am J Surg Pathol. 2017;41(11):1523-1531. doi: 10.1097/PAS.0000000000000910. PMID: 28719466.
- Makise N, Sekimizu M, Kubo T, Wakai S, Hiraoka N, Komiyama M, Fukayama M, Kawai A, Ichikawa H, Yoshida A. Clarifying the Distinction Between Malignant Peripheral Nerve Sheath Tumor and Dedifferentiated Liposarcoma: A Critical Reappraisal of the Diagnostic Utility of MDM2 and H3K27me3 Status. Am J Surg Pathol. 2018;42(5):656-664. doi: 10.1097/PAS.0000000000001014. PMID: 29309298.
- Yoshida A, Makise N, Wakai S, Kawai A, Hiraoka N. INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. Mod Pathol. 2018;31(5):744-752. doi: 10.1038/modpathol.2017.189. PMID: 29327709.
- Makise N, Sekimizu M, Kubo T, Wakai S, Watanabe SI, Kato T, Kinoshita T, Hiraoka N, Fukayama M, Kawai A, Ichikawa H, Yoshida A. Extraskeletal osteosarcoma: MDM2 and H3K27me3 analysis of 19 cases suggest disease heterogeneity. Histopathology. 2018;73(1):147-156. doi: 10.1111/his.13506. PMID: 29489027.
- Makise N, Sekimizu M, Konishi E, Motoi T, Kubo T, Ikoma H, Watanabe SI, Okuma T, Hiraoka N, Fukayama M, Kawai A, Ichikawa H, Yoshida A. H3K27me3 deficiency defines a subset of dedifferentiated chondrosarcomas with characteristic clinicopathological features. Mod Pathol. 2018. [Epub ahead of print] doi: 10.1038/s41379-018-0140-5. PMID: 30291346.
- Sekimizu M, Yoshida A, Mitani S, Asano N, Hirata M, Kubo T, Yamazaki F, Sakamoto H, Kato M, Makise N, Mori T, Yamazaki N, Sekine S, Oda I, Watanabe SI, Hiraga H, Yonemoto T, Kawamoto T, Naka N, Funauchi Y, Nishida Y, Honoki K, Kawano H, Tsuchiya H, Kunisada T, Matsuda K, Inagaki K, Kawai A, Ichikawa H. Frequent mutations of genes encoding vacuolar H+ -ATPase components in granular cell tumors. Genes Chromosomes Cancer 2018. [Epub ahead of print] doi: 10.1002/gcc.22727. PMID: 30597645.
- Kobayashi H, Makise N, Ushiku T, Ito N, Koga M, Shinoda Y, Tanaka S. Infiltrative nature of tumor-induced osteomalacia lesions in bone: Correlation between radiological and histopathological features. J Orthop Sci. 2019. [Epub ahead of print] DOI: 10.1016/j.jos.2019.02.005. PMID: 30797665.
- Makise N, Sekimizu M, Kobayashi E, Yoshida H, Fukayama M, Kato T, Kawai A, Ichikawa H, Yoshida A. Low-grade endometrial stromal sarcoma with a novel MEAF6-SUZ12 fusion. Virchows Arch. 2019 May 17. doi: 10.1007/s00428-019-02588-8. [Epub ahead of print] PMID: 31101969